Immunological mechanisms of sublingual immunotherapy
نویسندگان
چکیده
منابع مشابه
Immunological mechanisms of sublingual immunotherapy.
Administration of allergen-specific immunotherapy by the oral route, sublingual immunotherapy (SLIT), has been shown to be effective, with an improved safety profile compared with subcutaneous administration. However, the precise mechanisms underlying the induction of immune tolerance by SLIT remain unclear. Contact of the allergen with the antigen-presenting cells in oral mucosa is likely to b...
متن کاملEsophageal dysfunction and immunological changes induced by grass sublingual immunotherapy.
Sublingual immunotherapy frequently causes local oropharyngeal adverse events which are usually of mild severity, and tend to be self-limited and disappear within the first weeks of therapy. The mechanism of action involves changes in the specific humoral response to allergens, with increases in allergen-specific immunoglobulin G4 (IgG4) and blunting of the seasonal increase in allergen-specifi...
متن کاملAllergen-specific immunotherapy: update on immunological mechanisms.
UNLABELLED Immunotherapy selectively modulates the allergen-specific immune response. It involves the gradual administration of increasing amounts of allergen for the purpose of inducing protective immunological changes and it is the only curative approach for specific type I allergy. AIM Description of the allergic inflammation.- Comprehension of the early cellular changes after specific imm...
متن کاملNatural rubber latex allergy in children: clinical and immunological effects of 3-years sublingual immunotherapy.
BACKGROUND We previously demonstrated that one year of sublingual immunotherapy (SLIT) with natural rubber latex (NRL) was safe and efficacious in paediatric patients with NRL allergy. RESEARCH DESIGN AND METHODS We studied 12 NRL-allergic children (age 4-15), previously assigned to the treated arm of a double-blind placebo controlled study, who received a commercial latex SLIT for three year...
متن کاملHow does sublingual immunotherapy work?
There is now a growing consensus that specific sublingual immunotherapy (SLIT) does actually work. Initial skepticism about the results of uncontrolled or open studies has been removed after the positive outcomes of a series of large, double-blind, placebo-controlled trials. A recent meta-analysis found 21 trials of SLIT that were of sufficient quality to merit analysis of their efficacy agains...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Allergy
سال: 2006
ISSN: 0105-4538,1398-9995
DOI: 10.1111/j.1398-9995.2006.01159.x